18F-NaF (Radio-Flu) is a radioactive diagnostic agent for positron emission tomography (PET) indicated for imaging of bone to define areas of altered osteogenic activity.
Because of its binding to bone mineral, 18F (sodium fluoride) is taken up 3-10 times more in bone regions affected by malignant processes with resulting osteoblastic activity or osteolytic defects than in unaffected adjacent bone. Non-cancerous traumatic, erosive or inflammatory lesions of bone structure are also associated with increased osteogenesis. Sodium fluoride (18F) is therefore a marker of the reactive bone processes of cancerous or traumatic conditions. It also detects nonmalignant regions of physiologically or pathologically increased bone metabolism.